New research: Scientists determine structure of a DNA damage ‘First Responder’ protein

News Update

Scientists at the Sloan Kettering Institute have debunked a 20-year guiding paradigm for how the  9-1-1 clamp – a protein involved in the initiation of DNA repair protein – works by using cryo-electron microscopy to uncover how its protein structures fit together.  

In surprise findings, the researchers discovered the mechanism of action used by the 9-1-1 clamp is very different to what they previously believed. These findings could be the key to developing more effective  cancer treatments that specifically tackle the DNA repair pathway in cancer cells.

Therapeutics tackling cellular DNA repair responses are an exciting new area of development for cancer treatments, and one that Patrys is exploring with our deoxymab technology.

Read the research study.